If you are 65 or older, use this drug with care. Talk with your doctor if this drug stops working well. Be sure to have a nitrate-free period of time each day. ISOSORBIDE MONONITRATE TAB,SA has a VA Formualry status of Formulary Item and is within VA copay tier level 1. If you have been taking this drug for a long time without a break, it may not work as well. Long-term ISMN treatment may impair endothelial function in patients with CAD. ISOSORBIDE MONONITRATE TAB,SA (Formulary Item) is an item listed by VA within the class ANTIANGINALS. There were no significant changes in serum superoxide dismutase, malondialdehyde, and hypersensitive C-reactive protein levels in the two groups. There was a significant difference in the changes in FMD when the two groups were compared (-0.64☑.83 vs. The FMD decreased significantly (from 5.97☒.88 to 5.33☒.56%) in the ISMN group, whereas it increased from 6.27☓.23 to 6.96☒.84% in the control group after treatment for 1 year. See contact details ATC code: C01DA14 About Medicine Pharmacy Healthcare. Furthermore, serum superoxide dismutase, malondialdehyde, and hypersensitive C-reactive protein levels were also measured at baseline and follow-up. Isosorbide Mononitrate Tablets Information - Isosorbide. The primary endpoint was the change in brachial artery endothelium-dependent dilation from baseline to follow-up. In this prospective, double-blinded, placebo-controlled, randomized, single-center study, 60 patients were assigned to treatment with ISMN 20 mg retarded release orally twice per day (ISMN group, n=30) or placebo (control group, n=30) for 1 year. The purpose of this study was to evaluate the effects of long-term isosorbide mononitrate (ISMN) treatment on oxidative stress and endothelial function in patients with CAD. It remains unclear whether oxidative stress impairs endothelial function in patients with coronary artery disease (CAD) during long-term oral use of nitrates. Sustained use of nitrates is associated with adverse effects on vascular function by increasing oxidative stress.
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